Data quality in genomics and microarrays
نویسندگان
چکیده
منابع مشابه
Genetics and genomics: gene expression microarrays.
Since its development almost 2 decades ago, gene expression microarray technology has generated excitement and raised expectations for dramatic discoveries of underlying disease mechanisms. The general concept of a gene expression microarray is relatively straightforward. Messenger RNA is extracted from a biospecimen. Examples of biospecimens include cells grown in culture, tissue from animal m...
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Compared to a decade ago, genomics scientists, driven by technical changes and availability of massive genomic data, are performing a wider plurality of curation roles including those of end-users, curators, or dual-role users. Scientists with different curation roles (including that of end user) may focus on different data quality aspects and skills requirements in a community curation environ...
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The last decade provided biologists with wealth of DNA sequence information. This rich resource is now being utilized to create microarrays as a platform for investigating gene expression profiles as well as epigenetic DNA modifications and DNA-protein interactions on the genome-wide scale. An overview of the microarray technology and its applications in basic and applied life sciences will be ...
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The scale of testing required in clinical analysis has of necessity driven analytical methods to a variety of multiplexed formats. A single assay in a test tube has evolved to automated multiple testing in cuvettes in multicuvette carousels, or wells of a microplate with up to 9600 wells (1 ). Other formats for multiplex testing include 2-dimensional microarrays of spots of reagents on a planar...
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ژورنال
عنوان ژورنال: Nature Biotechnology
سال: 2006
ISSN: 1087-0156,1546-1696
DOI: 10.1038/nbt0906-1112